Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy

Hepatitis B virus (HBV) infection afflicts millions worldwide, causing cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a soluble variant of the viral capsid protein. HBeAg is not required for viral replication but is implicated in establishing immune tol...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhuang, Xiaolei, Watts, Norman R., Palmer, Ira W., Kaufman, Joshua D., Dearborn, Altaira D., Trenbeath, Joni L., Eren, Elif, Steven, Alasdair C., Rader, Christoph, Wingfield, Paul T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633136/
https://ncbi.nlm.nih.gov/pubmed/28842495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802272
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