The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly

HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oligomerizes cooperatively onto an RNA motif, the Rev-response element (RRE), forming a complex that engages with the host nuclear export machinery. To better understand Rev oligomerization, we determined four crystal...

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Bibliographic Details
Published in:Structure
Main Authors: DiMattia, Michael A., Watts, Norman R., Cheng, Naiqian, Huang, Rick, Heymann, J. Bernard, Grimes, Jonathan M., Wingfield, Paul T., Stuart, David I., Steven, Alasdair C.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938712/
https://ncbi.nlm.nih.gov/pubmed/27265851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.015
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