Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element

HIV-1 Rev is a small regulatory protein that mediates the nuclear export of viral mRNAs, an essential step in the HIV replication cycle. In this process Rev oligomerizes in association with a highly structured RNA motif, the Rev response element. Crystallographic studies of Rev have been hampered by...

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Detalhes bibliográficos
Main Authors: DiMattia, Michael A., Watts, Norman R., Stahl, Stephen J., Rader, Christoph, Wingfield, Paul T., Stuart, David I., Steven, Alasdair C., Grimes, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851902/
https://ncbi.nlm.nih.gov/pubmed/20231488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914946107
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