HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings

We describe a novel interaction between HIV-1 Rev and microtubules (MTs) that results in the formation of bilayered rings that are 44–49 nm in external diameter, 3.4–4.2 MD (megadaltons) in mass, and have 28-, 30-, or 32-fold symmetry. Ring formation is not sensitive to taxol, colchicine, or microtu...

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Bibliographic Details
Main Authors: Watts, Norman R., Sackett, Dan L., Ward, Rita D., Miller, Mill W., Wingfield, Paul T., Stahl, Stephen S., Steven, Alasdair C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2180222/
https://ncbi.nlm.nih.gov/pubmed/10908577
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