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A Cell-penetrating Antibody Fragment against HIV-1 Rev Has High Antiviral Activity: CHARACTERIZATION OF THE PARATOPE

The HIV-1 protein Rev oligomerizes on viral transcripts and directs their nuclear export. Previously, a Fab against Rev generated by phage display was used to crystallize and solve the structure of the Rev oligomerization domain. Here we have investigated the capability of this Fab to block Rev olig...

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Main Authors: Zhuang, Xiaolei, Stahl, Stephen J., Watts, Norman R., DiMattia, Michael A., Steven, Alasdair C., Wingfield, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106338/
https://ncbi.nlm.nih.gov/pubmed/24878961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581090
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