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A Cell-penetrating Antibody Fragment against HIV-1 Rev Has High Antiviral Activity: CHARACTERIZATION OF THE PARATOPE
The HIV-1 protein Rev oligomerizes on viral transcripts and directs their nuclear export. Previously, a Fab against Rev generated by phage display was used to crystallize and solve the structure of the Rev oligomerization domain. Here we have investigated the capability of this Fab to block Rev olig...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4106338/ https://ncbi.nlm.nih.gov/pubmed/24878961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581090 |
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