Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

Amyloid β (Aβ)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's disease (AD) brain, but whether and how plaques induce these neuritic abnormalities remain unknown. We tested the hypothesis that soluble oligomeric assemblies of Aβ, which surround plaques, induce calciu...

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Main Authors: Wu, Hai-Yan, Hudry, Eloise, Hashimoto, Tadafumi, Kuchibhotla, Kishore, Rozkalne, Anete, Fan, Zhanyun, Spires-Jones, Tara, Xie, Hong, Arbel-Ornath, Michal, Grosskreutz, Cynthia L., Bacskai, Brian J., Hyman, Bradley T.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841957/
https://ncbi.nlm.nih.gov/pubmed/20164348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4456-09.2010
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