Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

Amyloid β (Aβ)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's disease (AD) brain, but whether and how plaques induce these neuritic abnormalities remain unknown. We tested the hypothesis that soluble oligomeric assemblies of Aβ, which surround plaques, induce calciu...

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Autori principali: Wu, Hai-Yan, Hudry, Eloise, Hashimoto, Tadafumi, Kuchibhotla, Kishore, Rozkalne, Anete, Fan, Zhanyun, Spires-Jones, Tara, Xie, Hong, Arbel-Ornath, Michal, Grosskreutz, Cynthia L., Bacskai, Brian J., Hyman, Bradley T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841957/
https://ncbi.nlm.nih.gov/pubmed/20164348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4456-09.2010
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