Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

BACKGROUND: Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer’s disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological effects. Even though AD mouse models remain a valuable resource to investigate am...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Arbel-Ornath, Michal, Hudry, Eloise, Boivin, Josiah R., Hashimoto, Tadafumi, Takeda, Shuko, Kuchibhotla, Kishore V., Hou, Steven, Lattarulo, Carli R., Belcher, Arianna M., Shakerdge, Naomi, Trujillo, Pariss B., Muzikansky, Alona, Betensky, Rebecca A., Hyman, Bradley T., Bacskai, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361864/
https://ncbi.nlm.nih.gov/pubmed/28327181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0169-9
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