Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques

Although the clustering of GFAP immunopositive astrocytes around amyloid-β plaques in Alzheimer’s disease has led to the widespread assumption that plaques attract astrocytes, recent studies suggest that astrocytes stay put in injury. Here we reexamine astrocyte migration to plaques, using quantitat...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Galea, Elena, Morrison, Will, Hudry, Eloise, Arbel-Ornath, Michal, Bacskai, Brian J., Gómez-Isla, Teresa, Stanley, H. Eugene, Hyman, Bradley T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697430/
https://ncbi.nlm.nih.gov/pubmed/26644572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516779112
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