Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease

Amyloid β (Aβ) peptides, the main pathological species associated with Alzheimer's disease (AD), disturb intracellular calcium homeostasis, which in turn activates the calcium-dependent phosphatase calcineurin (CaN). CaN activation induced by Aβ leads to pathological morphological changes in ne...

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Detalhes bibliográficos
Main Authors: Hudry, Eloise, Wu, Hai-Yan, Arbel-Ornath, Michal, Hashimoto, Tadafumi, Matsouaka, Roland, Fan, Zhanyun, Spires-Jones, Tara L., Betensky, Rebecca A., Bacskai, Brian J., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296329/
https://ncbi.nlm.nih.gov/pubmed/22378890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6439-11.2012
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