Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

The accumulation of aggregated amyloid-β (Aβ) in amyloid plaques is a neuropathological hallmark of Alzheimer's disease (AD). Reactive astrocytes are intimately associated with amyloid plaques; however, their role in AD pathogenesis is unclear. We deleted the genes encoding two intermediate fil...

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Detalhes bibliográficos
Main Authors: Kraft, Andrew W., Hu, Xiaoyan, Yoon, Hyejin, Yan, Ping, Xiao, Qingli, Wang, Yan, Gil, So Chon, Brown, Jennifer, Wilhelmsson, Ulrika, Restivo, Jessica L., Cirrito, John R., Holtzman, David M., Kim, Jungsu, Pekny, Milos, Lee, Jin-Moo
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528309/
https://ncbi.nlm.nih.gov/pubmed/23038755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-208660
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