Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

BACKGROUND: Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer’s disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological effects. Even though AD mouse models remain a valuable resource to investigate am...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Neurodegener
Päätekijät: Arbel-Ornath, Michal, Hudry, Eloise, Boivin, Josiah R., Hashimoto, Tadafumi, Takeda, Shuko, Kuchibhotla, Kishore V., Hou, Steven, Lattarulo, Carli R., Belcher, Arianna M., Shakerdge, Naomi, Trujillo, Pariss B., Muzikansky, Alona, Betensky, Rebecca A., Hyman, Bradley T., Bacskai, Brian J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361864/
https://ncbi.nlm.nih.gov/pubmed/28327181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0169-9
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