Deletion of IGF-I Receptor (IGF-IR) in Primary Osteoblasts Reduces GH-Induced STAT5 Signaling

GH promotes longitudinal growth and regulates multiple cellular functions in humans and animals. GH signals by binding to GH receptor (GHR) to activate the tyrosine kinase, Janus kinase 2 (JAK2), and downstream pathways including signal transducer and activator of transcription 5 (STAT5), thereby re...

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Bibliografiske detaljer
Main Authors: Gan, Yujun, Zhang, Yue, DiGirolamo, Douglas J., Jiang, Jing, Wang, Xiangdong, Cao, Xuemei, Zinn, Kurt R., Carbone, David P., Clemens, Thomas L., Frank, Stuart J.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840807/
https://ncbi.nlm.nih.gov/pubmed/20133448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0357
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