Deletion of IGF-I Receptor (IGF-IR) in Primary Osteoblasts Reduces GH-Induced STAT5 Signaling

GH promotes longitudinal growth and regulates multiple cellular functions in humans and animals. GH signals by binding to GH receptor (GHR) to activate the tyrosine kinase, Janus kinase 2 (JAK2), and downstream pathways including signal transducer and activator of transcription 5 (STAT5), thereby re...

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Main Authors: Gan, Yujun, Zhang, Yue, DiGirolamo, Douglas J., Jiang, Jing, Wang, Xiangdong, Cao, Xuemei, Zinn, Kurt R., Carbone, David P., Clemens, Thomas L., Frank, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840807/
https://ncbi.nlm.nih.gov/pubmed/20133448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0357
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