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Functional Collaboration of Insulin-Like Growth Factor-1 Receptor (IGF-1R), but Not Insulin Receptor (IR), With Acute GH Signaling in Mouse Calvarial Cells

GH signals through the GH receptor (GHR), a cytokine receptor linked to Janus kinase 2 (JAK2). GH activates signal transducer and activator of transcription 5 (STAT5), causing expression of genes including IGF-I. IGF-I binds IGF-I receptor (IGF-IR), a heterotetrameric (α(2)-β(2)) tyrosine kinase gro...

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Bibliografske podrobnosti
Main Authors: Gan, Yujun, Paterson, Andrew J., Zhang, Yue, Jiang, Jing, Frank, Stuart J.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929739/
https://ncbi.nlm.nih.gov/pubmed/24302626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1732
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