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Functional Collaboration of Insulin-Like Growth Factor-1 Receptor (IGF-1R), but Not Insulin Receptor (IR), With Acute GH Signaling in Mouse Calvarial Cells
GH signals through the GH receptor (GHR), a cytokine receptor linked to Janus kinase 2 (JAK2). GH activates signal transducer and activator of transcription 5 (STAT5), causing expression of genes including IGF-I. IGF-I binds IGF-I receptor (IGF-IR), a heterotetrameric (α(2)-β(2)) tyrosine kinase gro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929739/ https://ncbi.nlm.nih.gov/pubmed/24302626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1732 |
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