Human GH Receptor-IGF-1 Receptor Interaction: Implications for GH Signaling

GH signaling yields multiple anabolic and metabolic effects. GH binds the transmembrane GH receptor (GHR) to activate the intracellular GHR-associated tyrosine kinase, Janus kinase 2 (JAK2), and downstream signals, including signal transducer and activator of transcription 5 (STAT5) activation and I...

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Detalles Bibliográficos
Main Authors: Gan, Yujun, Buckels, Ashiya, Liu, Ying, Zhang, Yue, Paterson, Andrew J., Jiang, Jing, Zinn, Kurt R., Frank, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2014
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213361/
https://ncbi.nlm.nih.gov/pubmed/25211187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1174
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