Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R)

Human growth hormone (GH) binds and activates GH receptor (GHR) and prolactin (PRL) receptor (PRLR). LNCaP human prostate cancer cells express only GHR. A soluble fragment of IGF-1 receptor (IGF-1R) extracellular domain (sol IGF-1R) interacts with GHR and blocks GH signaling. We now explore sol IGF-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Cell Endocrinol
Päätekijät: Zhang, Yue, Gc, Sajina, Patel, Sweta B., Liu, Ying, Paterson, Andrew J., Kappes, John C., Jiang, Jing, Frank, Stuart J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613819/
https://ncbi.nlm.nih.gov/pubmed/31100495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2019.05.004
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