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TIMP3 Modulates GHR Abundance and GH Sensitivity

GH receptor (GHR) binds GH at the cell surface via its extracellular domain and initiates intracellular signal transduction, resulting in important anabolic and metabolic actions. GH signaling is subject to dynamic regulation, which in part is exerted by modulation of cell surface GHR levels. Consti...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Zhang, Yue, Wang, Xiangdong, Loesch, Kimberly, May, Larry A., Davis, George E., Jiang, Jing, Frank, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884343/
https://ncbi.nlm.nih.gov/pubmed/27075707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1302
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