Endotoxin-Induced Proteolytic Reduction in Hepatic Growth Hormone (GH) Receptor: A Novel Mechanism for GH Insensitivity

GH is an important anabolic hormone. We previously demonstrated in cell culture that the cell surface GH receptor (GHR) is susceptible to inducible metalloproteolytic cleavage that yields the shed receptor extracellular domain (called GH binding protein) and renders the cells desensitized to subsequ...

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Detalhes bibliográficos
Main Authors: Wang, Xiangdong, Jiang, Jing, Warram, Jason, Baumann, Gerhard, Gan, Yujun, Menon, Ram K., Denson, Lee A., Zinn, Kurt R., Frank, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2422827/
https://ncbi.nlm.nih.gov/pubmed/18323468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0561
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