Defective membrane expression of human growth hormone (GH) receptor causes Laron-type GH insensitivity syndrome.
Mutations in the growth hormone receptor (GHR) gene can cause growth hormone (GH) resistance. Given the sequence homology between the extracellular domain of the GHR and a soluble GH-binding protein (GH-BP), it is remarkable that GH-BP binding activity is absent from the serum of patients with Laron...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52910/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1719554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.22.10272 |
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