IGF-1R Modulation of Acute GH-Induced STAT5 Signaling: Role of Protein Tyrosine Phosphatase Activity

GH is a potent anabolic and metabolic factor that binds its cell surface receptor (GHR), activating the GHR-associated tyrosine kinase, Janus kinase 2, which phosphorylates and activates the latent transcription factor, signal transducer and activator of transcription 5 (STAT5). Some GH actions are...

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Detalhes bibliográficos
Main Authors: Gan, Yujun, Zhang, Yue, Buckels, Ashiya, Paterson, Andrew J., Jiang, Jing, Clemens, Thomas L., Zhang, Zhong-Yin, Du, Keyong, Chang, Yingzi, Frank, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805849/
https://ncbi.nlm.nih.gov/pubmed/24030252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1178
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