Elevated GH/IGF-I, Due to Somatotrope-Specific Loss of Both IGF-I and Insulin Receptors, Alters Glucose Homeostasis and Insulin Sensitivity in a Diet-Dependent Manner

A unique mouse model was developed with elevated endogenous GH (2- to 3-fold) and IGF-I (1.2- to 1.4-fold), due to somatotrope-specific Cre-mediated inactivation of IGF-I receptor (IgfIr) and insulin receptor (Insr) genes (IgfIr,Insr(rGHpCre), referred to as HiGH mice). We demonstrate that the metab...

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Main Authors: Gahete, Manuel D., Córdoba-Chacón, José, Anadumaka, Chike V., Lin, Qing, Brüning, Jens C., Kahn, C. Ronald, Luque, Raúl M., Kineman, Rhonda D.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Growth Hormone-Somatostatin-GRH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230054/
https://ncbi.nlm.nih.gov/pubmed/21990313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1447
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