Replacement of Fhit in cancer cells suppresses tumorigenicity
The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions. Fhit hydrolyzes dinucleotide 5′,5‴-P(1),P(3)-triphosphate in vitro and mutation of a central histidi...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28382/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391102/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13771 |
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