Replacement of Fhit in cancer cells suppresses tumorigenicity

The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions. Fhit hydrolyzes dinucleotide 5′,5‴-P(1),P(3)-triphosphate in vitro and mutation of a central histidi...

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Detalhes bibliográficos
Main Authors: Siprashvili, Zurab, Sozzi, Gabriella, Barnes, Larry D., McCue, Peter, Robinson, Angela K., Eryomin, Vladimir, Sard, Laura, Tagliabue, Elda, Greco, Angela, Fusetti, Lisa, Schwartz, Gary, Pierotti, Marco A., Croce, Carlo M., Huebner, Kay
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC28382/
https://ncbi.nlm.nih.gov/pubmed/9391102
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