Replacement of Fhit in cancer cells suppresses tumorigenicity

The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions. Fhit hydrolyzes dinucleotide 5′,5‴-P(1),P(3)-triphosphate in vitro and mutation of a central histidi...

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Bibliografiske detaljer
Main Authors: Siprashvili, Zurab, Sozzi, Gabriella, Barnes, Larry D., McCue, Peter, Robinson, Angela K., Eryomin, Vladimir, Sard, Laura, Tagliabue, Elda, Greco, Angela, Fusetti, Lisa, Schwartz, Gary, Pierotti, Marco A., Croce, Carlo M., Huebner, Kay
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC28382/
https://ncbi.nlm.nih.gov/pubmed/9391102
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