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FHIT gene therapy prevents tumor development in Fhit-deficient mice

The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfe...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dumon, Kristoffel R., Ishii, Hideshi, Fong, Louise Y. Y., Zanesi, Nicola, Fidanza, Vincenzo, Mancini, Rita, Vecchione, Andrea, Baffa, Raffaele, Trapasso, Francesco, During, Matthew J., Huebner, Kay, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30656/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248081/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061020098
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