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Replisome stalling and stabilization at CGG repeats that are responsible for chromosomal fragility
Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Yeast Tof1 and Mrc1 proteins facilitate replication fork progression through CGG repeats. Remarkably, t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837601/ https://ncbi.nlm.nih.gov/pubmed/19136957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1527 |
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