Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

Expansion of triplex-forming GAA/TTC repeats in the first intron of FXN gene results in Friedreich's ataxia. Besides FXN, there are a number of other polymorphic GAA/TTC loci in the human genome where the size variations thus far have been considered to be a neutral event. Using yeast as a mode...

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Main Authors: Kim, Hyun-Min, Narayanan, Vidhya, Mieczkowski, Piotr A, Petes, Thomas D, Krasilnikova, Maria M, Mirkin, Sergei M, Lobachev, Kirill S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580784/
https://ncbi.nlm.nih.gov/pubmed/18833189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.205
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