Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich’s ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger g...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhang, Yu, Shishkin, Alexander A., Nishida, Yuri, Marcinkowski-Desmond, Dana, Saini, Natalie, Volkov, Kirill V., Mirkin, Sergei M., Lobachev, Kirill S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635072/
https://ncbi.nlm.nih.gov/pubmed/22959270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.002
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares