Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich’s ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger g...

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Главные авторы: Zhang, Yu, Shishkin, Alexander A., Nishida, Yuri, Marcinkowski-Desmond, Dana, Saini, Natalie, Volkov, Kirill V., Mirkin, Sergei M., Lobachev, Kirill S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635072/
https://ncbi.nlm.nih.gov/pubmed/22959270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.002
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