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Mosaic HIV-1 Vaccines Expand the Breadth and Depth of Cellular Immune Responses in Rhesus Monkeys

The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development 1-2. Antigens derived from natural HIV-1 sequences have elicited only limited breadth of cellular immune responses in nonhuman primate studies and clinical trials to date. Polyvalent “mosaic” antigens, in co...

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Bibliographische Detailangaben
Hauptverfasser: Barouch, Dan H., O'Brien, Kara L., Simmons, Nathaniel L., King, Sharon L., Abbink, Peter, Maxfield, Lori F., Sun, Ying-Hua, La Porte, Annalena, Riggs, Ambryice M., Lynch, Diana M., Clark, Sarah L., Backus, Katherine, Perry, James R., Seaman, Michael S., Carville, Angela, Mansfield, Keith G., Szinger, James J., Fischer, Will, Muldoon, Mark, Korber, Bette
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834868/
https://ncbi.nlm.nih.gov/pubmed/20173752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2089
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