Mosaic HIV-1 Vaccines Expand the Breadth and Depth of Cellular Immune Responses in Rhesus Monkeys

The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development 1-2. Antigens derived from natural HIV-1 sequences have elicited only limited breadth of cellular immune responses in nonhuman primate studies and clinical trials to date. Polyvalent “mosaic” antigens, in co...

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Detalhes bibliográficos
Main Authors: Barouch, Dan H., O'Brien, Kara L., Simmons, Nathaniel L., King, Sharon L., Abbink, Peter, Maxfield, Lori F., Sun, Ying-Hua, La Porte, Annalena, Riggs, Ambryice M., Lynch, Diana M., Clark, Sarah L., Backus, Katherine, Perry, James R., Seaman, Michael S., Carville, Angela, Mansfield, Keith G., Szinger, James J., Fischer, Will, Muldoon, Mark, Korber, Bette
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834868/
https://ncbi.nlm.nih.gov/pubmed/20173752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2089
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