Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens

To create an HIV-1 vaccine that generates sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus, we have been exploring vaccines based on consensus and mosaic protein designs. Increasing the valency of a mosaic immunogen cocktail increases...

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Détails bibliographiques
Auteurs principaux: Santra, Sampa, Muldoon, Mark, Watson, Sydeaka, Buzby, Adam, Balachandran, Harikrishnan, Carlson, Kevin R., Mach, Linh, Kong, Wing-Pui, McKee, Krisha, Yang, Zhi-Yong, Rao, Srinivas S., Mascola, John R., Nabel, Gary J., Korber, Bette T., Letvin, Norman L.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582221/
https://ncbi.nlm.nih.gov/pubmed/22521913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.012
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