Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens

To create an HIV-1 vaccine that generates sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus, we have been exploring vaccines based on consensus and mosaic protein designs. Increasing the valency of a mosaic immunogen cocktail increases...

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Detalhes bibliográficos
Main Authors: Santra, Sampa, Muldoon, Mark, Watson, Sydeaka, Buzby, Adam, Balachandran, Harikrishnan, Carlson, Kevin R., Mach, Linh, Kong, Wing-Pui, McKee, Krisha, Yang, Zhi-Yong, Rao, Srinivas S., Mascola, John R., Nabel, Gary J., Korber, Bette T., Letvin, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582221/
https://ncbi.nlm.nih.gov/pubmed/22521913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.012
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