Immune Control of an SIV Challenge by a T Cell-Based Vaccine in Rhesus Monkeys

A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans1, 2. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing SIV Gag failed to reduce peak or setpoint viral loads following...

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Detalhes bibliográficos
Main Authors: Liu, Jinyan, O’Brien, Kara L., Lynch, Diana M., Simmons, Nathaniel L., La Porte, Annalena, Riggs, Ambryice M., Abbink, Peter, Coffey, Rory T., Grandpre, Lauren E., Seaman, Michael S., Landucci, Gary, Forthal, Donald N., Montefiori, David C., Carville, Angela, Mansfield, Keith G., Havenga, Menzo J., Pau, Maria G., Goudsmit, Jaap, Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614452/
https://ncbi.nlm.nih.gov/pubmed/18997770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07469
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