Mucosal Trafficking of Vector-Specific CD4(+) T Lymphocytes following Vaccination of Rhesus Monkeys with Adenovirus Serotype 5

Post hoc analysis of the phase 2b Step study evaluating a recombinant adenovirus serotype 5 (rAd5)-based HIV-1 vaccine candidate suggested a potential increased risk of HIV-1 acquisition in subjects who were baseline Ad5 seropositive and uncircumcised. These concerns had a profound impact on the HIV...

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Main Authors: Masek-Hammerman, Katherine, Li, Hualin, Liu, Jinyan, Abbink, Peter, La Porte, Annalena, O'Brien, Kara L., Whitney, James B., Carville, Angela, Mansfield, Keith G., Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937774/
https://ncbi.nlm.nih.gov/pubmed/20686023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01157-10
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