Characterization of scavengers of γ-ketoaldehydes that do not inhibit prostaglandin biosynthesis

Expression of cyclooxygenase-2 (COX-2) is associated with the development of many pathologic conditions. The product of COX-2, prostaglandin H(2) (PGH(2)) can spontaneously rearrange to form reactive γ-ketoaldehydes called levuglandins (LGs). This γ-ketoaldehyde structure confers a high degree of re...

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Hauptverfasser: Zagol-Ikapitte, Irene, Amarnath, Venkataraman, Bala, Manju, Roberts, L. Jackson, Oates, John A., Boutaud, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831641/
https://ncbi.nlm.nih.gov/pubmed/20041722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900407a
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