Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS

Levels of reactive γ-ketoaldehydes derived from arachidonate increase in diseases associated with inflammation and oxidative injury. To assess the biological importance of these γ-ketoaldehydes, we previously identified salicylamine as an effective γ-ketoaldehyde scavenger in vitro and in cells. To...

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Main Authors: Zagol-Ikapitte, Irene, Matafonova, Elena, Amarnath, Venkataraman, Bodine, Christopher L., Boutaud, Olivier, Tirona, Rommel G., Oates, John A., Roberts, L. Jackson, Davies, Sean S.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150493/
https://ncbi.nlm.nih.gov/pubmed/21822464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics2010018
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