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Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice

Both inflammation and oxidative injury are features of Alzheimer’s disease (AD), but the contribution of these intertwined phenomena to the loss of working memory in this disease is unclear. We tested the hypothesis that highly reactive γ-ketoaldehydes that are formed both by non-enzymatic free radi...

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Detalhes bibliográficos
Main Authors: Davies, Sean S., Bodine, Chris, Matafonova, Elena, Pantazides, Brooke G., Bernoud-Hubac, Nathalie, Harrison, Fiona E., Olson, Sandra J., Montine, Thomas J., Amarnath, Venkataraman, Roberts, L. Jackson
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289064/
https://ncbi.nlm.nih.gov/pubmed/21709376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-102118
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