PYRIDOXAMINE ANALOGS SCAVENGE LIPID-DERIVED γ-KETOALDEHYDES AND PROTECT AGAINST H(2)O(2)-MEDIATED CYTOTOXICITY

Isoketals and levuglandins are highly reactive γ-ketoaldehydes formed by oxygenation of arachidonic acid in settings of oxidative injury and cyclooxygenase activation, respectively. These compounds rapidly adduct to proteins via lysyl residues, which can alter protein structure/function. We examined...

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Main Authors: Davies, Sean S., Brantley, Eric J., Voziyan, Paul A., Amarnath, Venkataraman, Zagol-Ikapitte, Irene, Boutaud, Olivier, Hudson, Billy G., Oates, John A., Jackson Roberts, L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597444/
https://ncbi.nlm.nih.gov/pubmed/17176098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061860g
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