Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers

The thromboxane synthase converts prostaglandin H(2) to thromboxane A(2) and malondialdehyde (MDA) in approximately equimolar amounts. A reactive dicarbonyl, MDA forms covalent adducts of amino groups, including the ε-amine of lysine, but the importance of this reaction in platelets was unknown. Uti...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Zagol-Ikapite, Irene, Sosa, Iberia R., Oram, Denise, Judd, Audra, Amarnath, Kalyani, Amarnath, Venkataraman, Stec, Donald, Oates, John A., Boutaud, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Patient-Oriented and Epidemiological Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617406/
https://ncbi.nlm.nih.gov/pubmed/26378094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P063271
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