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Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions.
Products of lipid peroxidation include a number of reactive lipid aldehydes such as malondialdehyde, 4-hydroxy-nonenal, 4-oxo-nonenal, and isolevuglandins (IsoLGs). Although these all contribute to disease processes, the most reactive are the IsoLGs, which rapidly adduct to lysine and other cellular...
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| Udgivet i: | Pharmacol Ther |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7495735/ https://ncbi.nlm.nih.gov/pubmed/31629006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2019.107418 |
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