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Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions.

Products of lipid peroxidation include a number of reactive lipid aldehydes such as malondialdehyde, 4-hydroxy-nonenal, 4-oxo-nonenal, and isolevuglandins (IsoLGs). Although these all contribute to disease processes, the most reactive are the IsoLGs, which rapidly adduct to lysine and other cellular...

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Bibliografiske detaljer
Udgivet i:Pharmacol Ther
Main Authors: Davies, Sean D., May-Zhang, Linda S., Boutaud, Olivier, Amarnath, Venkataraman, Kirabo, Annet, Harrison, David G.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495735/
https://ncbi.nlm.nih.gov/pubmed/31629006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2019.107418
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