Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

BACKGROUND: Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) is one of the predominant isoform...

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Bibliografiske detaljer
Main Authors: Zhou, Ming, Zhao, Yuhua, Ding, Yan, Liu, Hao, Liu, Zixing, Fodstad, Oystein, Riker, Adam I, Kamarajugadda, Sushama, Lu, Jianrong, Owen, Laurie B, Ledoux, Susan P, Tan, Ming
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829492/
https://ncbi.nlm.nih.gov/pubmed/20144215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-33
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