Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

BACKGROUND: Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) is one of the predominant isoform...

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Detalhes bibliográficos
Main Authors: Zhou, Ming, Zhao, Yuhua, Ding, Yan, Liu, Hao, Liu, Zixing, Fodstad, Oystein, Riker, Adam I, Kamarajugadda, Sushama, Lu, Jianrong, Owen, Laurie B, Ledoux, Susan P, Tan, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829492/
https://ncbi.nlm.nih.gov/pubmed/20144215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-33
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