Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

BACKGROUND: Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) is one of the predominant isoform...

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Hlavní autoři: Zhou, Ming, Zhao, Yuhua, Ding, Yan, Liu, Hao, Liu, Zixing, Fodstad, Oystein, Riker, Adam I, Kamarajugadda, Sushama, Lu, Jianrong, Owen, Laurie B, Ledoux, Susan P, Tan, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829492/
https://ncbi.nlm.nih.gov/pubmed/20144215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-33
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