Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

The Warburg effect, which reflects cancer cells' preference for aerobic glycolysis over glucose oxidation, contributes to tumor growth, progression and therapy resistance. The restraint on pyruvate flux into mitochondrial oxidative metabolism in cancer cells is in part attributed to the inhibit...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jin, Yue, Cai, Qingsong, Shenoy, Anitha K., Lim, Sangbin, Zhang, Ying, Charles, Steve, Tarrash, Miriam, Fu, Xueqi, Kamarajugadda, Sushama, Trevino, Jose G., Tan, Ming, Lu, Jianrong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041892/
https://ncbi.nlm.nih.gov/pubmed/26848621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7159
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