Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

The Warburg effect, which reflects cancer cells' preference for aerobic glycolysis over glucose oxidation, contributes to tumor growth, progression and therapy resistance. The restraint on pyruvate flux into mitochondrial oxidative metabolism in cancer cells is in part attributed to the inhibit...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Jin, Yue, Cai, Qingsong, Shenoy, Anitha K., Lim, Sangbin, Zhang, Ying, Charles, Steve, Tarrash, Miriam, Fu, Xueqi, Kamarajugadda, Sushama, Trevino, Jose G., Tan, Ming, Lu, Jianrong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041892/
https://ncbi.nlm.nih.gov/pubmed/26848621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7159
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