Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase

OBJECTIVE: Tumor cells rely heavily on glycolysis regardless of oxygen tension, a phenomenon called the Warburg effect. Hexokinase II (HKII) catalyzes the first irreversible step of glycolysis and is often overexpressed in tumor cells. Mitochondrial HKII couples glycolysis and oxidative phosphorylat...

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Bibliografiska uppgifter
I publikationen:Chin J Cancer Res
Huvudupphovsmän: Luo, Fangxiu, Li, You, Yuan, Fei, Zuo, Junli
Materialtyp: Artigo
Språk:Inglês
Publicerad: AME Publishing Company 2019
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613503/
https://ncbi.nlm.nih.gov/pubmed/31354221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21147/j.issn.1000-9604.2019.03.14
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