Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex

Signal transducer and activator 5a (STAT5A) is a classical transcription factor that plays pivotal roles in various biological processes, including tumor initiation and progression. A fraction of STAT5A is localized in the mitochondria, but the biological functions of mitochondrial STAT5A remain obs...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Liang, Zhang, Jianong, Liu, Yan, Zhang, Pingzhao, Nie, Ji, Zhao, Rui, Shi, Qin, Sun, Huiru, Jiao, Dongyue, Chen, Yingji, Zhao, Xiaying, Huang, Yan, Li, Yao, Zhao, Jian-Yuan, Xu, Wei, Zhao, Shi-Min, Wang, Chenji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214628/
https://ncbi.nlm.nih.gov/pubmed/34148062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03908-0
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