Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts

Eukaryotic cell metabolism consists of processes that generate available energy, such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (Oxphos), and those that consume it, including macromolecular synthesis, the maintenance of ionic gradients, and cellular detoxificat...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Huabo, Lu, Jie, Kulkarni, Sucheta, Zhang, Weiqi, Gorka, Joanna E., Mandel, Jordan A., Goetzman, Eric S., Prochownik, Edward V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462518/
https://ncbi.nlm.nih.gov/pubmed/30755479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005200
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