Inhibition of hepatocellular carcinoma by metabolic normalization

In two different mouse liver cancer models, we recently showed that a switch from oxidative phosphorylation (Oxphos) to glycolysis (the Warburg effect) is invariably accompanied by a marked decline in fatty acid oxidation (FAO) and a reciprocal increase in the activity of pyruvate dehydrogenase (PDH...

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Veröffentlicht in:PLoS One
Hauptverfasser: Wang, Huabo, Lu, Jie, Dolezal, James, Kulkarni, Sucheta, Zhang, Weiqi, Chen, Angel, Gorka, Joanna, Mandel, Jordan A., Prochownik, Edward V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594671/
https://ncbi.nlm.nih.gov/pubmed/31242205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218186
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