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Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell Model

Neurodegeneration in Parkinson's disease (PD) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose detectable respiratory activity associated with depletion of intact mitochondrial DNA (mtDNA). Replenishment of mtDNA might improve...

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Autori principali: Keeney, Paula M., Quigley, Caitlin K., Dunham, Lisa D., Papageorge, Christina M., Iyer, Shilpa, Thomas, Ravindar R., Schwarz, Kathleen M., Trimmer, Patricia A., Khan, Shaharyar M., Portell, Francisco R., Bergquist, Kristen E., Bennett, James P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829286/
https://ncbi.nlm.nih.gov/pubmed/19374590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.023
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