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Recombinant Human Mitochondrial Transcription Factor A Stimulates Mitochondrial Biogenesis and ATP Synthesis, Improves Motor Function after MPTP, Reduces Oxidative Stress and Increases Survival after Endotoxin

Recombinant human mitochondrial transcription factor A protein (rhTFAM) was evaluated for its acute effects on cultured cells and chronic effects in mice. Fibroblasts incubated with rhTFAM acutely increased respiration in a chloramphenicol-sensitive manner. SH-SY5Y cells showed rhTFAM concentration-...

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Detalhes bibliográficos
Main Authors: Thomas, Ravindar R., Khan, Shaharyar M., Portell, Francisco R., Smigrodzki, Rafal M., Bennett, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005536/
https://ncbi.nlm.nih.gov/pubmed/20727424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2010.08.004
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